Between 1996 and 2009, ISMP published dozens of errors about chloral hydrate used for sedation involving mostly dosing errors, oversedation, and administration of the oral liquid by the IV route. The events we published included 8 that resulted in death. In two of the cases, technical support … See more Since 2010, ISMP has not received additional reports of errors involving pediatric sedation with chloral hydrate, which we assumed was due in large part to the 2012 … See more Chloral hydrate has been a drug of choice for pediatric sedation in some facilities due to its low cost.5 However, in regards to efficacy, there are … See more In June 2014, Nordt et al. published three cases of pediatric chloral hydrate overdoses, one a fatality, that occurred in the outpatient setting … See more In addition to the risk of respiratory depression associated with most sedatives used for pediatric sedation, chloral hydrate carries several other risks worthy of mention: Resedation after discharge. Chloral hydrate can … See more WebJan 26, 2024 · The use of Chloral Hydrate Oral Solution in children and adolescents is not generally recommended and if used should be under the supervision of a medical …
Chloral hydrate: the good and the bad - PubMed
WebA potential caution concerning the widespread use of chloral hydrate in infants and children is that chloral hydrate, trichloroethanol, and trichloroacetic acid all are metabolites of trichloroethylene, an industrial solvent, environmental contaminant, and carcinogen. Chloral hydrate is also a mutagen and can cause chromosomal damage. WebUsual Adult Dose for Sedation. Hypnotic: 500 to 1000 mg orally 15 to 30 minutes before bedtime; use for less than 2 weeks. Premedicant: 500 to 1000 mg orally 30 … knights logo on helmet
Position statement 2103 Off label use of Chloral Hydrate in …
Webtreatment, was found in 89% of the children administered chloral hydrate and promethazine compared with 72% adminstered chloral hydrate alone. Vital signs remained essentially unchanged throughout all treatments. The only adverse side effect noted was vomiting in 14% of the administrations with promethazine and 48% without. WebNov 6, 2013 · Chloral hydrate was effective in inducing sleep in 97%, however, 34% of the children woke up spontaneously before the test was completed, particularly those with chronic neurological abnormalities ... Webchloral hydrate is administered in the management of alcohol withdrawal symptoms, the usual dose is 500 mg–1 g repeated at 6-h intervals if needed. Generally, single doses or daily dosage for adults should not exceed 2 g. The sedative dose of chloral hydrate for children is 8 mg/kg bw or 250 mg/m2 of body surface area three times a day, with ... knights logo black and white