Cisplatin transporter

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August undefined, 2024

WebMay 17, 2024 · They postulated that cisplatin could compete with copper for CTR1-mediated transport, but did not further investigate the consequences on copper homeostasis or potential modification of CTR1. Platinum coordination may also alter conformation or block necessary amino acids for native Cu (I) interactions. WebIn addition, cisplatin is the standard treatment of patients with non-small cell lung cancer (NSCLC) when druggable mutations are not present in the tumour 34. Hence, Pt drugs have not been...

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WebApr 30, 2015 · Cisplatin is one of the first-line platinum-based chemotherapeutic agents for treatment of many types of cancer, including ovary cancer. CTR1 (copper transporter 1), a transmembrane solute carrier transporter, has previously been shown to increase the cellular uptake and sensitivity of cisplatin. It is hypothesized that increased CTR1 … WebMar 9, 2024 · SLC11A2, also known as DMT1 (divalent metal transporter 1), is a metal transporter that has been shown to control the pool of cytoplasmic iron 32, therefore affecting the drug activation step... phi phi island cabana hotel agoda

Biomolecules Free Full-Text Cisplatin Resistance: Genetic and ...

WebJul 3, 2024 · Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for this toxicity has not been … WebJan 17, 2024 · System x c − is one among many amino acid transporters expressed in the plasma membrane of mammalian cells 1.This transporter is composed of xCT (SLC7A11), which is the substrate-specific ... WebFeb 10, 2024 · Cisplatin is a chemotherapeutic drug widely used to treat various types of cancers, including testicular, ovarian, bladder, head and neck, lung, and cervical cancers. However, patients treated with cisplatin frequently suffer from nausea, vomiting, fatigue, serious kidney problems, tinnitus and hearing loss. phi phi island by speedboat reviews

Magnesium co-administration decreases cisplatin-induced …

MATE1 - Transporters - Solvo Biotechnology

WebDec 14, 2024 · Cisplatin (CDDP) is a chemotherapy drug commonly used in systemic treatment of germ cell tumors, including cancers of the ovaries, testes, and solid tumors of the head and neck 1. WebMay 20, 2024 · Once the tissue culture system was set up and characterized for further analysis, it was investigated how cisplatin affects drug transporter expression of CR cell lines if treated with carboplatin, paclitaxel, or their combination. These drugs were specifically selected as they are clinically relevant in the treatment of AC-s [43,44,45]. phi phi island early birdWebOct 5, 2014 · The uptake of cisplatin is mediated by the copper transporter Ctr1 in yeast and mammals (Ishida, Lee et al., 2002). It has been further confirmed in human cells that cisplatin triggers rapid degradation of the copper membrane transporter CTR1, with diminished influx of cisplatin, resulting in resistance to the drug ( Lin, Okuda et al., 2002 ... phi phi island day trip

"WebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, generating genetic and epigenetic changes that lead to the generation of resistance and the activation of intrinsic resistance mechanisms in cancer cells. Among them, we can find mutations, … " - Cisplatin transporter

Cisplatin transporter

Role of transporters in the distribution of platinum-based …

WebCisplatin is mainly internalised by the copper transporter CTR1. Accordingly, CTR1 down-regulation has been associated with resistance to platinum-based drugs in cancer [ 10 , 11 ]. Cellular inactivation of cisplatin and subsequent sequestration can be mediated by binding to cytoplasmic nucleophilic factors, including glutathione (GSH) and ...

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Web(mate1) mediate cellular transport of cisplatin. Transporter mediated uptake has been shown to be an important process mediating cellular accumulation of cisplatin. Cisplatin is one of the most widely utilized antitumor drugs in the world [6]. Cisplatin was the first platinum-based drug that revolutionized the treatment of neoplastic diseases. WebSep 6, 2012 · Cisplatin is a potent cytostatic drug, whose use is limited by its severe acute and chronic nephro-, oto-, and peripheral neurotoxicity. For this reason, other platinum derivatives, such as carboplatin and oxaliplatin, with less toxicity but still with antitumoral action have been developed.

WebThese transporters have a large binding site containing partially overlapping interaction domains for different substrates and are specifically distributed around the body. … WebThe direction of MATE1 transport is defined by the proton concentration gradient: when assayed in vitro at pH 7.4 or higher, MATE1 behaves as an uptake transporter, whereas …

WebJul 22, 2009 · Organic cation transporter 2 (OCT2) has been implicated in the cellular uptake of cisplatin, but its role in cisplatin-induced nephrotoxicity remains unknown. In mice, deletion of Oct1 and Oct2 resulted in significantly impaired urinary excretion of cisplatin without an apparent influence on plasma levels. WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …

WebApr 26, 2024 · Full article: Update on drug-drug interaction at organic cation transporters: mechanisms, clinical impact, and proposal for advanced in vitro testing Expert Opinion on Drug Metabolism & Toxicology Volume 17, 2024 - Issue 6 Open access 2,926 Views 2 CrossRef citations to date 0 Altmetric Listen Review

WebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, ... membrane-bound mechanosensitive sodium … phi phi island excursionsWebwww.ncbi.nlm.nih.gov phi phi island day toursWebCisplatin, or cis-diamminedichloridoplatinum(II) cis-[PtCl 2 (NH 3) 2], is a platinum-based anticancer drug largely used for the treatment of various types of cancers, including … phi phi island day tripsWebHydroxytyrosol protects against cisplatin-induced nephrotoxicity via attenuating CKLF1 mediated inflammation, and inhibiting oxidative stress and apoptosis. ... of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-κ B pathway and regulating transporter mediated drug efflux. Journal of Ethnopharmacology, 2024 ... phi phi island day tourWebFeb 23, 2007 · Ctr1, the major copper influx transporter, has been convincingly demonstrated to transport cisplatin and its analogues, carboplatin, and oxaliplatin. … phi phi island flughafenWebThe copper transporter 1 seems to be of particular importance for cisplatin uptake in tumor cells, while the organic cation transporter (OCT) 2, due to its specific organ distribution, may play a major role in the development of undesired cisplatin side effects. phi phi island day trip from krabiWebFeb 10, 2024 · Cisplatin is a chemotherapeutic drug widely used to treat various types of cancers, including testicular, ovarian, bladder, head and neck, lung, and cervical cancers. However, patients treated with cisplatin frequently suffer from nausea, vomiting, fatigue, serious kidney problems, tinnitus and hearing loss. tspc 5/2-stf-7.62