WebJun 23, 2024 · Cyclophilin D (CypD) is a peptidyl-prolyl isomerase expressed in the nucleus and transported into the mitochondria where it is best associated with the regulation of the mitochondrial permeability transition pore (MPTP). There are, however, other possible roles of CypD in the mitochondria which may … WebCypD is a peptidyl prolyl isomerase F that resides in the mitochondrial matrix, associates with the inner mitochondrial membrane, and plays a central role in the opening of the mPTP during the mitochondrial membrane permeability transition ( Rao et al., 2014; Du et al., 2008; Khaspekov et al., 1999; Valasani et al., 2014b ).

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