Eif5a wikipedia
WebEukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene. It is the only known protein to contain the unusual amino acid hypusine [N ε … WebSep 28, 2006 · Furthermore, we detected imatinib-induced down-regulation of eIF5A, a protein highly conserved from yeast to mammalian cells. 36,37 eIF5A precursor is the only cellular protein known to contain a specific lysine residue (Lys50), which is converted to the unique amino acid hypusine, thereby enabling activation of eIF5A. Hypusination is …
Eif5a wikipedia
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WebATF1 NM_005171; ATF2 NM_001880; ATF4 Activating transcription factor 4 NM_001675; ATF6 NM_007348; ATF7 NM_001206682; ATF7IP NM_018179; BTF3 NM_001207 Homo sapiens basic transcription factor … WebDec 17, 2024 · One such protein is the translation factor eIF5a, one of the top 20 most abundant proteins in CD8 + T cells 2. eIF5a was originally identified as a translation initiation factor, but may also ...
Web208691 Ensembl ENSG00000163577 ENSMUSG00000050192 UniProt Q9GZV4 Q8BGY2 RefSeq (mRNA) NM_020390 NM_177586 RefSeq (protein) NP_065123 NP_808254 Location (UCSC) Chr 3: 170.89 – 170.91 Mb Chr 3: 28.84 – 28.85 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Eukaryotic translation initiation factor 5A-2 … WebApr 10, 2024 · eIF5A has been shown to regulate a number of gene products specifically, termed the eIF5A regulon, and its role in translating proline-rich sequences has recently …
WebEukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene. [1] It is the only known protein to contain the unusual amino acid hypusine … WebSep 3, 2024 · For Dohh and Eif5a KD, AML12 cells were transfected with Dohh, Eif5a siRNA, or negative control siRNA for 48. For lipid loading, AML12 cells were seeded in 96-well plates, and treated with 0.5% ...
WebJul 17, 2024 · Hypusine [Nε-(4-amino-2-hydroxybutyl)lysine] is a derivative of lysine that is formed post-translationally in the eukaryotic initiation factor 5A (eIF5A). Its occurrence at a single site in one cellular protein defines hypusine synthesis as one of the most specific post-translational modifications. Synthesis of hypusine involves two enzymatic steps: …
WebJun 9, 2024 · The eukaryotic initiation factor 5A is an 18-kD protein composed of 154 amino acids. It contains a unique amino acid residue, hypusine, that is formed … box fans cheapeIF5 is a GTPase-activating protein, which helps the large ribosomal subunit associate with the small subunit. It is required for GTP-hydrolysis by eIF2. eIF5A is the eukaryotic homolog of EF-P. It helps with elongation and also plays a role in termination. EIF5A contains the unusual amino acid hypusine. eIF5B is a GTPase, and is involved in assembly of the full ribosome. It is the functional eukaryoti… guoyin li subject reviewWebAug 1, 2014 · THE essential eIF5A protein is highly conserved from archaea to mammals, and has a distant ortholog, EF-P, in eubacteria (Park et al. 2010).Interestingly, eIF5A is the only known protein to undergo a unique and essential post-translational modification to form the hypusine residue, and this modification is necessary for its interaction with the 80S … guo youshouWebNational Center for Biotechnology Information box fan shroudWebFeb 5, 2024 · Fig. 1: Heterozygous variants in EIF5A cause a novel craniofacial-neurodevelopmental disorder. a Individuals with de novo heterozygous missense … guoyong ecust.edu.cnWebApr 29, 2024 · Hypusination is a unique posttranslational modification of eIF5A, a eukaryotic translation factor. Hypusine is a rare amino acid synthesized in this process and is mediated by two enzymes, deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH). Despite the essential participation of this conserved eIF5A protein in plant development … box fans for shopEukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene. It is the only known protein to contain the unusual amino acid hypusine [N -(4-amino-2-hydroxybutyl)-lysine], which is synthesized on eIF5A at a specific lysine residue from the polyamine spermidine … See more Germline deleterious heterozygous EIF5A variants cause Faundes-Banka syndrome. This rare human disorder is characterized by variable combinations of developmental delay, microcephaly, micrognathia and dysmorphic features. See more • Bevec D, Hauber J (1997). "Eukaryotic initiation factor 5A activity and HIV-1 Rev function". Biological Signals. 6 (3): 124–133. doi:10.1159/000109118. PMID 9285095 See more guoyu holding limited