WebIntended Use. The AmoyDx® HANDLE HRR NGS Panel (Reversible Terminator Sequencing) is intended for qualitative detection of single nucleotide variants (SNVs) and insertions and deletions (Indels) variants in protein coding regions and intron/exon boundaries of 27 HRR genes (AR, ATM, ATR, BARD1, BRCA1, BRCA2, BRIP1, CDH1, … Web1 aug. 2024 · The RNA polymerase II-associated kinase cyclin-dependent kinase (CDK) 12 also appears to selectively affect transcription and splicing of several HRR genes, including BRCA1 and BRCA2.Thus, modulation of BRCA1/2 expression is a straightforward mechanism that may alter HRR function. Besides their role in promoting HRR at several …
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WebRead through this recent paper that takes a closer look into the role of homologous recombination repair (HRR) genes in uterine leiomyosarcomas:… WebDescription: Homo sapiens DNA polymerase epsilon, catalytic subunit (POLE), mRNA. (from RefSeq NM_006231) RefSeq Summary (NM_006231): This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with … little creatures next door
Human Gene POLE (ENST00000320574.10) from GENCODE V43
WebDNA was extracted from formalin-fixed, paraffin-embedded sections and analyzed for mutations using a 21-gene panel (including 13 well-known HRR genes) by next … Web2 dec. 2024 · In The Lancet Oncology, Joaquin Mateo and colleagues1 report the results of the TOPARP-B trial, in which selected patients with metastatic castration-resistant prostate cancer and DNA damage response (DDR) gene aberrations were found to be responsive to the poly(ADP–ribose) polymerase (PARP) inhibitor, olaparib. Their study adds to the … Web13 dec. 2024 · Targeted gene sequencing of all blood samples was performed at GloriousMed Clinical Laboratory Co., Ltd. (Shanghai, China). Sequence data analysis, including identification of germline mutations, somatic mutations, copy number alterations, and quality control; and the list of DDR and HRR genes are described in Supplementary … little creatures from star wars